发明名称 |
Modified oligonucleotides for telomerase inhibition |
摘要 |
Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
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申请公布号 |
US7494982(B2) |
申请公布日期 |
2009.02.24 |
申请号 |
US20040938184 |
申请日期 |
2004.09.09 |
申请人 |
GERON CORPORATION |
发明人 |
GRYAZNOV SERGEI;PONGRACZ KRISZTINA |
分类号 |
A01N43/04;A61K31/70;A61K48/00;C07H21/02;C07H21/04;C12N;C12N5/00;C12N15/113 |
主分类号 |
A01N43/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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