发明名称 |
Crystal structure of FMS-like tyrosine kinase |
摘要 |
The invention relates to FMS-like tyrosine kinase (FLT3), FLT3 binding pockets or FLT3-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to FMS-like tyrosine kinase protein, complexes of FMS-like tyrosine kinase protein, homologues thereof, or FLT-3-like protein or protein complexes. The invention also relates to crystallizable compositions and crystals comprising an FMS-like tyrosine kinase cytoplasmic domain or homologues thereof. The invention also relates to methods of identifying inhibitors of the cytoplasmic domain of FMS-like tyrosine kinase protein.
|
申请公布号 |
US7494795(B2) |
申请公布日期 |
2009.02.24 |
申请号 |
US20040941387 |
申请日期 |
2004.09.15 |
申请人 |
GRIFFITH JAMES PAUL;BLACK JAMES ROGER;FAERMAN CARLOS H;SWENSON LOVORKA LORA;WYNN MICHAEL ANDREW;LU FAN;LIPPKE JUDITH A;SAXENA KUMKUM |
发明人 |
GRIFFITH JAMES PAUL;BLACK JAMES ROGER;FAERMAN CARLOS H.;SWENSON LOVORKA LORA;WYNN MICHAEL ANDREW;LU FAN;LIPPKE JUDITH A.;SAXENA KUMKUM |
分类号 |
C12N9/10;C12N9/12;G01N31/00;G01N33/68 |
主分类号 |
C12N9/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|