| 摘要 |
The present invention relates to a compound represented by the following formula (I): <CHEM> (wherein, W represents W<A>-A<1> -W<B> - (in which, W<A> is substituted or unsubstituted aryl, etc., A<1> is -NR<1>-, single bond, -C(O)-, etc., and W<B> is substituted or unsubstituted arylene, etc.), R is single bond, -NH-, -OCH2-, alkenylene, etc., X is -C(O) -CH2-, etc., and M is, for example, the following formula: <CHEM> (in which, R<11>, R<12> and R<13> each independently represents hydrogen, hydroxyl, amino, halogen, etc., R<14> is hydrogen or lower alkyl, Y represents -CH2-O-, etc., Z is substituted or unsubstituted arylene, etc., A<2> is single bond, etc, and R<10> is hydroxyl or lower alkoxy)), or salt thereof; and a medicament containing the same. <??>This compound or salt thereof selectively inhibits binding of cell adhesion molecules to VAL-4 and exhibits high bioavailability so that it is useful as a preventive and/or remedy for inflammatory diseases, autoimmune diseases, metastasis, bronchial asthma, rhinostenosis, diabetes, and the like. |
