发明名称 |
Vagal Afferent Neurons as Targets for Treatment |
摘要 |
A method of identifying a compound capable of reducing or preventing prolonged sensory neuron hyper-excitability comprising the steps of: (a) administering the compound to an experimental non-human animal having prolonged sensory neuron hyper-excitability; (b) generating an expression profile of the genes modulated in the Nodose Ganglia (NG) of the animal of step (a); (c) comparing the expression profile obtained in (b) with the expression profile of a corresponding panel of genes expressed in the NG of an experimental non-human animal having no prolonged sensory neuron hyper-excitability; wherein a positive correlation of the expression profiles is indicative that the compound is capable of reducing or preventing prolonged sensory neuron hyper-excitability in NG.
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申请公布号 |
US2009048194(A1) |
申请公布日期 |
2009.02.19 |
申请号 |
US20060815688 |
申请日期 |
2006.02.08 |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
AERSSENS JEROEN MARCEL MARIA ROGER;PEETERS PIETER JOHAU;MEULEMANS ANN LOUISE GABRIELLE;COULIE BERNARD;HILLSLEY KIRK;GRUNDY DAVID;STEAD RONALD |
分类号 |
A61K31/70;A61P1/00;C12Q1/68;C40B30/04;C40B40/08 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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