Diagnostic and therapeutic target cdc2l6 proteins for neurodegenerative diseases

摘要

The present invention discloses a dysregulation of the CDC2L6 gene and the protein products thereof in Alzheimer's disease patients. Based on this finding, the invention provides methods for diagnosing and prognosticating Alzheimer's disease in a subject, and for determining whether a subject is at increased risk of developing Alzheimer's disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating and preventing Alzheimer's disease and related neurodegenerative disorders using the CDC2L6 gene and its corresponding gene products. Screening methods for modulating agents of neurodegenerative diseases are also disclosed.