发明名称 |
HUCBC TREATMENT OF AMYLOID ASSOCIATED DISEASE |
摘要 |
Administration of human umbilical cord blood cells (HUCBC) or HUCBC-derived plasma is used to treat amyloid-based diseases, such as Alzheimer's disease, Huntington's disease, cerebral amyloid antigopathy, and type-II diabetes. Modulating inflammatory reactions by infusing HUCBC resulted in a marked reduction of amyloid plaques and immune-associated cellular damage. HUCBC infusion also significantly reduced cerebral amyloid angiopathy in mice models. These effects were associated with suppression of the CD40-CD40L interaction and a reduction in surface expressed CD-40 was observed on immune cells. Further, A? phagocytic activity was increased and soluble and insoluble AB protein levels were modulated by treatment. HUCBC-infused sera also significantly increased phagocytosis of AB 1-42 peptide and inhibited immune cell CD40 expression and reduced cerebral amyloid angiopathy. |
申请公布号 |
WO2009023814(A2) |
申请公布日期 |
2009.02.19 |
申请号 |
WO2008US73265 |
申请日期 |
2008.08.15 |
申请人 |
UNIVERSITY OF SOUTH FLORIDA;TAN, JUN;SANBERG, PAUL, R. |
发明人 |
TAN, JUN;SANBERG, PAUL, R. |
分类号 |
A61K48/00;C12N5/08 |
主分类号 |
A61K48/00 |
代理机构 |
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