| 发明名称 |
METHODS FOR TREATMENT AND PREVENTION OF OTOTOXICITY BY SIRNA |
| 摘要 |
<p>The present invention relates to methods for reducing and/or preventing ototoxicity caused by an ototoxic agent, noise or head and/or neck radiation. It is also directed to a method for preventing or reducing generation of reactive oxygen species in the inner ear of a patient. The methods of the present invention include administering at least one siRNA directed against TRPV1 mRNA, NOX3 mRNA or a combination thereof.</p> |
| 申请公布号 |
WO2009023025(A1) |
申请公布日期 |
2009.02.19 |
| 申请号 |
WO2007US75826 |
申请日期 |
2007.08.13 |
| 申请人 |
BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY;RAMKUMAR, VICKRAM;MUKHERJEA, DEBASHREE;RYBAK, LEN |
发明人 |
RAMKUMAR, VICKRAM;MUKHERJEA, DEBASHREE;RYBAK, LEN |
| 分类号 |
A01N43/04;A61K31/70;C07H21/04 |
主分类号 |
A01N43/04 |
| 代理机构 |
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代理人 |
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