发明名称 Novel process for the preparation of bisphosphonic acids
摘要 <p>The present invention relates to a process for the preparation of bisphosphonic acids and salts thereof, in particular monosodium salts thereof. The invention also relates to the conversion of the bisphosphonic acids to their sodium salts using an aqueous-organic solvent system. The present invention further relates to the conversion of variable hydrate forms of risedronic acid monosodium salt into a pharmaceutically acceptable hemipentahydrate form by crystallization using an aqueous-organic solvent system.</p>
申请公布号 AU2007270897(A8) 申请公布日期 2009.02.19
申请号 AU20070270897 申请日期 2007.07.03
申请人 MERCK DEVELOPMENT CENTRE PRIVATE LIMITED;GENERICS [UK] LIMITED 发明人 MANOJ M. GHADGE;REKHA M. AVADHUT;VINAY KUMAR SHUKLA;VINAYAK G. GORE
分类号 C07F9/38;C07F9/58 主分类号 C07F9/38
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