发明名称 |
Novel process for the preparation of bisphosphonic acids |
摘要 |
<p>The present invention relates to a process for the preparation of bisphosphonic acids and salts thereof, in particular monosodium salts thereof. The invention also relates to the conversion of the bisphosphonic acids to their sodium salts using an aqueous-organic solvent system. The present invention further relates to the conversion of variable hydrate forms of risedronic acid monosodium salt into a pharmaceutically acceptable hemipentahydrate form by crystallization using an aqueous-organic solvent system.</p> |
申请公布号 |
AU2007270897(A8) |
申请公布日期 |
2009.02.19 |
申请号 |
AU20070270897 |
申请日期 |
2007.07.03 |
申请人 |
MERCK DEVELOPMENT CENTRE PRIVATE LIMITED;GENERICS [UK] LIMITED |
发明人 |
MANOJ M. GHADGE;REKHA M. AVADHUT;VINAY KUMAR SHUKLA;VINAYAK G. GORE |
分类号 |
C07F9/38;C07F9/58 |
主分类号 |
C07F9/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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