USE OF RSK INHIBITORS TO IMPEDE INTRACELLULAR PATHOGEN INFECTIONS

摘要

A composition comprising a RSK activity inhibiting agent is provided for inhibiting the establishment or maintenance of an intracellular pathogenic infection by pathogens whose pathogenicity derives in part from the pathogens ability to impede endosomal/phagosomal maturation in the host cell. The RSK specific inhibitors used in accordance with the disclosed composition and methods can be selected from any inhibiting moiety including by not limited to anti-sense oligonucleotides, interfering oligonucleotide and kaempferol 3-O-(3",4"-di-O-acetyl- a-L-rhamnopyranoside) and related compounds.