发明名称 |
Compound Comprising Prodigiosin From Serratia Macescence B-1231 Kctc 0386Bp for Prevention and Treatment of Acute Graft-Versus-Host Disease |
摘要 |
This invention relates to a composition for the prevention and treatment of acute graft-versus-host disease comprising prodigiosin isolated from Serratia marcescence B-1231 KCTC 0386BP, as an effective ingredient. The prodigiosin is immunosup-pressive by selectively suppressing the proliferation of T-cells through the suppression of the expression of IL-2 receptors, which is needed for the activation of T-cells. Prodigiosin can be used either alone or in conjunction with cyclosporin A for greater effect, since the two substances have different mode of actions. These make prodigiosin effective for the prevention and treatment of acute graft-versus-host disease.
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申请公布号 |
US2009048328(A1) |
申请公布日期 |
2009.02.19 |
申请号 |
US20060988561 |
申请日期 |
2006.07.10 |
申请人 |
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY |
发明人 |
KIM HWAN MOOK;HAN SANG-BAE;LEE CHANG-WOO;LEE KI-HOON;PARK SUNG-KYU;LEE KI-HO;KANG JONG-SOON;YOON WON-KEE;KIM YOUNG-KOOK |
分类号 |
A61K31/4155;A61P37/06 |
主分类号 |
A61K31/4155 |
代理机构 |
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地址 |
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