POTASSIUM CHANNEL INHIBITORS

摘要

The present invention relates to a peptide or a pharmaceutically acceptable salt thereof comprising amino acid sequence 1: R1 xaa29xaa28c1xaa1xaa2xaa3xaa4xaa5xaa6xaa7xaa8c2xaa9xaa10xaa11xaa12c3xaa13xaa14xaa15 xaa16xaa17xaa18xaa19xaa20xaa21xaa22c4xaa23xaa24xaa25c5xaa26xaa27c6-R2 SEQ ID NO:1 wherein xaa17 is a positively charged D amino acid residue; xaa18 is an aromatic D amino acid residue; xaa1 to xaa16, xaa19 to xaa27 are each independently selected from any D amino acid residue; xaa28 and xaa29 are independently absent or are selected from any D amino acid residue; R1 is hydrogen or is an amino acid residue, an N- terminal capping group or an oligopeptide optionally capped with an N- terminal capping group; R2 is hydrogen or is an amino acid residue, a C -terminal capping group or an oligopeptide optionally capped with a C -terminal capping group; wherein each of c1 and c6 are independently selected from D-cysteine, D- homocysteine, D-penicillamine or D-selenocysteine and ci is linked to c6 through a disulfide, diseleno or sulfide-selenium bond; or both c1 and c6 are D-amino acid residues having a side chain double bond and the side chains of ci and c6 are linked to form a dicarba bond; and each of c2 to c5 are independently selected from D-cysteine and D-selenocysteine and c2 is linked to c4 and c3 is linked to c5 through disulfide, diseleno or sulfide-selenium bonds.