The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides a more efficient route for preparing the enone intermediate.
申请公布号
WO2008127361(A3)
申请公布日期
2009.02.19
申请号
WO2007US81076
申请日期
2007.10.11
申请人
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;MYERS, ANDREW, G.;BRUBAKER, JASON, D.