发明名称 METHOD OF PRODUCING HYALURONIC ACID DERIVATIVES
摘要 <p>A polysaccharide derivative having a high solubility in an aqueous solvent is produced. The production method of the present invention uses a compound shown by the general formula (1) as a condensing agent and allows a polysaccharide having a carboxyl group to react with an organic compound having a functional group capable of condensing with the carboxyl group to prepare the polysaccharide derivative: R1 and R2 independently represent a substituent selected among alkyl groups of 1 to 4 carbon atoms and aryl groups of 6 to 8 carbon atoms; Z-represents a counter anion; and E+represents an organic group shown as: R3, R4, and R5 independently represent an organic group having at least one carbon atom directly bound to a quaternary nitrogen atom and any two or all of R3, R4, and R5 may link together to form a cyclic structure.</p>
申请公布号 EP2024398(A1) 申请公布日期 2009.02.18
申请号 EP20070742990 申请日期 2007.04.27
申请人 SEIKAGAKU CORPORATION 发明人 YASUDA, YOUSUKE
分类号 C07D251/46;A61K47/48;C08B37/08 主分类号 C07D251/46
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