发明名称 |
Polymeric immunoglobulin receptor-mediated gene transfer |
摘要 |
<p>We report the successful transfer of reporter genes into the airway epithelium in vivo following the injection of a targeting complex consisting of the Fab portion of immunoglobulin G directed against the rat polymeric immunoglobulin receptor conjugated to poly (L-lysine), and noncovalently bound to plasmid DNA. This technique specifically delivered the transgene to the liver and lung, tissues in which this receptor is expressed.</p> |
申请公布号 |
EP2025757(A2) |
申请公布日期 |
2009.02.18 |
申请号 |
EP20070021848 |
申请日期 |
1997.06.03 |
申请人 |
CASE WESTERN RESERVE UNIVERSITY;WASHINGTON UNIVERSITY |
发明人 |
FERKOL, THOMAS W. JR.;DAVIS, PAMELA B.;ZIADY, ASSEM-GALAL;PERLMUTTER, DAVID |
分类号 |
C12N15/09;C12N15/87;A61K31/70;A61K31/7088;A61K35/76;A61K47/48;A61K48/00;C07H21/00;C07K14/47;C07K14/705;C07K16/18;C07K19/00;C12N5/10;C12N9/64 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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