| 发明名称 |
SYNTHESIS AND PURIFICATION OF HEPATITIS C VIRUS-LIKE PARTICLES |
| 摘要 |
<p>Production of enveloped RNA virus-like particles intracellularly in vitro in insect cells using a recombinant baculovirus vector containing a cDNA coding for viral structural proteins is disclosed. In vitro production and purification of hepatitis C virus (HCV)-like particles containing HCV core protein, E1 protein and E2 protein is disclosed. Production of antibodies in vivo to the purified HCV-like particles is disclosed.</p> |
| 申请公布号 |
EP0941337(B1) |
申请公布日期 |
2009.02.18 |
| 申请号 |
EP19970916252 |
申请日期 |
1997.03.25 |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
LIANG, T., JAKE;BAUMERT, THOMAS, F. |
| 分类号 |
C12N15/40;G01N33/576;A61K39/00;A61K39/29;A61P31/14;C07K14/18;C07K16/10;C12N5/10;C12N15/09;C12P21/02;G01N33/569 |
主分类号 |
C12N15/40 |
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