| 摘要 |
A method of preparing a D, L-cystine compound is provided to prepare a D, L-cystine compound with high efficiency and high concentration, used for drug additive, permanent medicine, cosmetic material and food nutrition intensifier through chlorination and organic synthesis. A method of preparing a D, L-cystine compound comprises (1) a step for manufacturing dichloro propionitrile indicated as the following chemical formula 3 by performing the chlorination addition of acrylonitrile indicated as the following chemical formula 2; (2) a step for manufacturing a thiazine derivative indicated as the chemical formula 5 by reacting dichloro propionitrile indicated as the chemical formula 3 and thiourea indicated as the chemical formula 4; (3) a step for manufacturing D,L-2-aminothiazoline-4-carboxylic acid indicated as the chemical formula 6 by adding a base to a thiazine derivative indicated as the chemical formula 5; (4) a step for manufacturing a mercapto thiazolidine carboxylic acid indicated as the chemical formula 8 by performing the hydrosulfurization of D,L-2-aminothiazoline-4-carboxy acid indicated as the chemical formula 6 and sodium bisulfide indicated as the chemical formula 7; (5) a step for manufacturing a cystein compound indicated as the chemical formula 9 by hydrolyzing a mercapto thiazolidine carboxylic acid indicated as the chemical formula 8; and (6) a step for manufacturing a cystine compound indicated as the chemical formula 1 by reacting a cystein compound indicated as the chemical formula 9.
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