发明名称 |
Human anti-human interleukin-18 antibody, fragment thereof and method for using same |
摘要 |
A human-derived human anti-human IL-18 antibody of the present invention is an antibody against human IL-18, the antibody including: an H-chain complementarity determining region consisting of (a) a polypeptide consisting of amino-acid sequences represented by SEQ ID NOS: 4 to 6, or (b) a polypeptide which is a mutant of the polypeptide (a) and which serves as the H-chain complementarity determining region; and an L-chain complementarity determining region against human interleukin-18 consisting of (c) a polypeptide consisting of amino-acid sequences represented by SEQ ID NOS: 10 to 12, or (d) a polypeptide which is a mutant of the polypeptide (c) and which serves as the L-chain complementarity determining region. This makes it possible to provide a human anti-human IL-18 antibody and a method for using the antibody.
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申请公布号 |
US7491803(B2) |
申请公布日期 |
2009.02.17 |
申请号 |
US20050555074 |
申请日期 |
2005.10.28 |
申请人 |
JAPAN SCIENCE & TECHNOLOGY AGENCY;JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE |
发明人 |
SUGIMURA KAZUHISA;NAKANISHI KENJI;NAKASHIMA TOSHIHIRO |
分类号 |
C07K16/00;A61P37/02;A61P43/00;C07K16/24;C12N15/09;C12P21/08 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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