发明名称 |
Uses of fibroblasts or supernatants from fibroblasts for the suppression of immune responses in transplantation |
摘要 |
Disclosed is a method of inducing a reduced immune response to a transplant in a recipient by treating said recipient with an amount of fibroblasts or a supernatant from a fibroblast culture effective to reduce or inhibit host rejection of the transplant. The fibroblasts or a supernatant from a fibroblast culture can be administered before, at the same time as, or after the transplant. This method is effective in reducing an immune response to a transplant without compromising the immune response to other foreign antigens. Also disclosed is a method of inducing a reduced immune response against a host by foreign tissue, i.e., graft versus host disease.
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申请公布号 |
US7491388(B1) |
申请公布日期 |
2009.02.17 |
申请号 |
US19990807810 |
申请日期 |
1999.11.04 |
申请人 |
OSIRIS THERAPEUTICS, INC. |
发明人 |
MC INTOSH KEVIN R.;MOSCA JOSEPH D.;KLYUSHNENKOVA ELENA N. |
分类号 |
A01N65/00;A61K45/00;A61K35/12;A61K35/14;A61K35/28;A61K35/36;A61P37/06 |
主分类号 |
A01N65/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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