发明名称 |
SUBSTITUIERTE PYRIDINE UND PYRIDAZINE MIT ANGIOGENESIS HEMMENDER WIRKUNG |
摘要 |
Substituted pyridines and pyridazines having angiogenesis inhibiting activity and generalized structural formula (I) wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R<1> and R<2> may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermeability processes using these materials are also disclosed. |
申请公布号 |
AT422494(T) |
申请公布日期 |
2009.02.15 |
申请号 |
AT20000978215T |
申请日期 |
2000.09.26 |
申请人 |
BAYER CORPORATION |
发明人 |
DUMAS, JACQUES;JOE, TEDDY;KLUENDER, HAROLD;LEE, WENDY;NAGARATHNAM, DHANAPALAN;SIBLEY, ROBERT;SU, NING;BOYER, STEPHEN;DIXON, JULIE |
分类号 |
C07D401/12;A61K31/4725;A61K31/50;A61K31/5025;A61P9/10;A61P17/06;A61P19/02;A61P29/00;A61P31/12;A61P31/22;A61P35/00;C07D237/04;C07D333/00;C07D401/06;C07D401/14;C07D403/12;C07D403/14;C07D405/14;C07D417/12;C07D417/14;C07D487/04;C07D491/04;C07D491/048;C07D495/04;C07D513/04 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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