发明名称 |
Pyrazine Derivatives Useful as Adenosine Receptor Antagonists |
摘要 |
The present disclosure relates to a compound of formula (I) wherein: A is an optionally substituted monocyclic or polycyclic aryl or heteroaryl group; B is an optionally substituted monocyclic nitrogen-containing heteroaryl group; and either a) R1 and R2 are chosen from a hydrogen atom and specified substituents, or b) R2, R1 and the -NH- group to which R1 is attached, form a moiety chosen from the moiety of formulae (IIa) and (IIb): or a pharmaceutically acceptable salt thereof, or a N-oxide thereof. The present disclosure also relates to a method for treating a subject afflicted with a pathological condition or disease susceptible to amelioration by antagonism of the A2B adenosine receptor.
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申请公布号 |
US2009042891(A1) |
申请公布日期 |
2009.02.12 |
申请号 |
US20060997048 |
申请日期 |
2006.07.25 |
申请人 |
VIDAL JUAN BERNAT;ESTEVE TRIAS CRISTINA;PUEYO LIDIA SOCA;EASTWOOD PAUL ROBERT |
发明人 |
VIDAL JUAN BERNAT;ESTEVE TRIAS CRISTINA;PUEYO LIDIA SOCA;EASTWOOD PAUL ROBERT |
分类号 |
A61K31/495;A61K31/4965;A61P11/06;C07D401/06;C07D471/04 |
主分类号 |
A61K31/495 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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