| 发明名称 |
COMBINATION MOTIF IMMUNE STIMULATORY OLIGONUCLEOTIDE WITH IMPROVED ACTIVITY |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a combination motif immunostimulatory oligonucleotide with improved activity. <P>SOLUTION: An immunostimulatory nucleic acid of 14-100 nucleotides in length comprising the formula: 5'X<SB>1</SB>DCGHX<SB>2</SB>3' and, in addition, a nucleic sequence selected from a group comprising P and N locating at 5' side just adjacent to X<SB>1</SB>or locating at 3' side just adjacent to X<SB>2</SB>is provided. In the nucleic acid, X<SB>1</SB>and X<SB>2</SB>independently represents an arbitrary sequence 0-10 nucleotides long; D represents a nucleotide except C; C represents cytosine, G represents guanine, H represents a nucleotide except G; N represents a B cell neutralizing sequence beginning with CGG trinucleotide and at least 10 nucleotides long; P represents a GC-rich palindrome-containing sequence at least 10 nucleotides long. <P>COPYRIGHT: (C)2009,JPO&INPIT |
| 申请公布号 |
JP2009028051(A) |
申请公布日期 |
2009.02.12 |
| 申请号 |
JP20080259120 |
申请日期 |
2008.10.03 |
| 申请人 |
COLEY PHARMACEUTICAL GMBH;UNIV OF IOWA RESEARCH FOUNDATION |
发明人 |
KRIEG ARTHUR M;VOLLMER JOERG;UHLMANN EUGEN |
| 分类号 |
C12N15/09;A61K31/7088;A61K31/7115;A61K38/00;A61K48/00;A61P11/06;A61P31/00;A61P35/00;A61P35/04;A61P37/04;A61P37/08;A61P43/00;C12N5/10;C12N15/11;C12N15/117;C12Q1/68 |
主分类号 |
C12N15/09 |
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