METHODS OF TREATING B-CELL CANCERS

摘要

The present invention is directed to methods of causing malignant B- cells and treating malignant B-cells. These methods involve the use of an inhibitor of PKK activity, whether active directly against PKK or effective to knockdown PKK expression, which when introduced into a malignant B cell (or administered to a patient) is effective to cause cell death of the malignant B cell, thereby treating the B- cell malignancy.