| 摘要 |
The present invention provides a method of photoregulating the formation of a peptide-protein complex by using a novel peptide in which a structural change for recognizing a protein is photoregulated, in the formation of a complex between a peptide capable of recognizing a protein and a protein of interest. A peptide having an intramolecular cross-linkage via a photocleavable cross-linking group, and method for producing the same. Further, a peptide which has an intramolecular cross-linkage via a photocleavable cross-linking group and forms a cyclic structure together with the cross-linking group, containing a peptide having an epitope corresponding to a functional protein or a ligand at a part which forms the cyclic structure, and method for producing the same. A reaction regulation method comprising the steps of: irradiating a peptide which comprises a peptide having the above epitope, with light to cause cleavage of the photocleavable cross-linking group, whereby dissociating the cyclic structure; and initiating a reaction between the peptide in which the cyclic structure has dissociated and the functional protein or the ligand to form a complex.
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