发明名称 |
PREPARATION OF SYNTHETIC NUCLEOSIDES VIA p-ALLYL TRANSITION METAL COMPLEX FORMATION |
摘要 |
<p>This invention provides highly regioselective and stereoselective processes for preparing synthetic nucleosides. A process for the preparation of synthetic nucleosides is provided that comprises a) preparing a bicycloamide derivative, b) reacting the bicycloamide derivative with a nucleic acid base or heterocyclic base or salt thereof in the presence of a transition metal catalyst to form a cyclopentenecarboxamide, and c) cleaving a carboxamide group from the cyclopentenecarboxamide to form the synthetic nucleoside. The processes according to the invention can be used for the synthesis of a variety of anti-viral agents, including Abacavir, Carbovir, and Entecavir, as well as derivatives thereof.</p> |
申请公布号 |
WO2009021114(A1) |
申请公布日期 |
2009.02.12 |
申请号 |
WO2008US72478 |
申请日期 |
2008.08.07 |
申请人 |
EMORY UNIVERSITY;LIOTTA, DENNIS, C.;LI, YONGFENG |
发明人 |
LIOTTA, DENNIS, C.;LI, YONGFENG |
分类号 |
C07D209/00;C07F9/00 |
主分类号 |
C07D209/00 |
代理机构 |
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代理人 |
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地址 |
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