MANUFACTURING METHOD OF DEXIBUPROFEN SALT

摘要

A method for manufacturing crystalline dexibuprofen salts is provided to steadily maintain white color, to ensure excellent solubility and to prepare crystalline dexibuprofen lysine salts used in various pharmacy fields. A method for manufacturing crystalline dexibuprofen salts comprises (i) a step for manufacturing mixture solution by mixing dexibuprofen, L- lysine and reaction solvent; (ii) a step for creating crystals by adding the crystallization solvent to the obtained mixture solution; and (iii) a step for filtering, washing and drying the crystals. The crystallization solvent is a mixture of ethylacetate or ethylacetate and isopropanol. The reaction solvent is a mixture of isopropanol and water or a mixture of isopropanol, ethylacetate and water.