IGFBP-2 C-TERMINAL FRAGMENTS AND USES THEREOF

摘要

There is increasing evidence that insulin-like growth factor (IGF)/insulin-like growth factor binding proteins exert cell-type specific IGFindependent effects in addition to IGF-modulating activty. Here, carboxyterminal IGFBP-2 fragments, IGFBP-2167-279, IGFBP-2167-289 and IGFBP- 2104289, were shown to exert a strong mitogenic effect on growth plate chondrocytes. Thus, a novel role of IGFBP-2 fragments is to effectuate endocrine and paracrine/autocrine regulation of longitudinal growth.