发明名称 |
LOCAL FIELD STIMULATION FOR CELL TRAINING OF A BIOLOGICAL PACEMAKER |
摘要 |
A system is provided for stimulating one or more cells, wherein the stimulation is sub-threshold and may alter a transmembrane potential of the one or more cells. For some populations of cells it may be possible to affect the transmembrane potential to gain a therapeutic benefit. Cells of the sino-atrial node spontaneously depolarize predominantly due to the slow depolarization of transmembrane potential. The present system may provide sino-atrial cells with a local field stimulation that while not eliciting an action potential may nonetheless alter local transmembrane potential. Such alteration of transmembrane potential may permit an increase or decrease in a rate of depolarization, and hence modify heart rate. |
申请公布号 |
WO2008140863(A3) |
申请公布日期 |
2009.02.12 |
申请号 |
WO2008US58144 |
申请日期 |
2008.03.25 |
申请人 |
CARDIAC PACEMAKERS, INC.;KENKNIGHT, BRUCE;GIROUARD, STEVEN, D. |
发明人 |
KENKNIGHT, BRUCE;GIROUARD, STEVEN, D. |
分类号 |
A61K35/34;A61M37/00;A61N1/362;A61P9/06;C12N5/077 |
主分类号 |
A61K35/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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