MAMMARY GLAND-SPECIFIC HUMAN ERYTHROPOIETIN EXPRESSION VECTOR, TRANSGENIC ANIMAL AND METHOD FOR PRODUCING HUMAN ERYTHROPOIETIN USING SAME

摘要

The present invention provides a mammary gland-specific human erythropoietin expression (hEPO) vector, transgenic animal and method for producing human erythropoietin using the same. The inventive hEPO-expressing transgenic animals express a mammary gland- specific EPO at an extremely higher concentration than the convention method. The hEPO produced from inventive transgenic animals shows better stability and superior physiological activity than those of the same kind of commercially available protein. Therefore, the inventive hEPO-expressing transgenic animals can be effectively used for production of EPO showing a superior physiological activity than the existing EPO.