发明名称 |
RAGE FUSION PROTEINS, FORMULATIONS, AND METHODS OF USE THEREOF |
摘要 |
<p>Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to the N-terminus of an immunoglobulin C H 2 domain. Also disclosed are RAGE fusion protein formulations and the use of the RAGE fusion proteins and RAGE fusion protein formulations as therapeutics for RAGE-mediated pathologies.</p> |
申请公布号 |
EP2021474(A2) |
申请公布日期 |
2009.02.11 |
申请号 |
EP20070794379 |
申请日期 |
2007.04.25 |
申请人 |
TRANSTECH PHARMA, INC. |
发明人 |
MJALLI, ADNAN M.M.;ROTHLEIN, ROBERT;TIAN, YE EDWARD;WEBSTER, JEFFREY C.;BENJAMIN, ERIC J. |
分类号 |
C12N15/13;A61K38/17;C07K14/705;C07K16/00;C12N15/62 |
主分类号 |
C12N15/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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