INHIBITORS AGAINST G6PD ENZYME FOR TREATING AND PREVENTING OXIDATIVE STRESS AND/OR INFLAMMATORY RELATED DISEASES AND METHOD FOR SCREENING THE SAME

摘要

A pharmaceutical composition comprising G6PD is provided to reduce the oxidative stress and inflammation which are closely related to metabolic disorder such as insulin resistance, type 2 diabetes, cardiovascular diseases and arteriosclerosis. The pharmaceutical composition for preventing and treating disease associated with oxidative stress and inflammation comprises G6PD(glucose-6-phosphate dehydrogenase) or its expression inhibitor such as dehydroepiandrosterone(DHEA) or its derivatives, which is selected from SEQ ID NO:1 to 6, preferably siRNA(small interfering RNA) of SEQ ID NO:5 or 6.