发明名称 |
Method for identification of T-cell epitopes and use for preparing molecules with reduced immunogenicity |
摘要 |
<p>This invention relates to a novel approach for identification of T-cell epitopes, that give rise to an immune reaction in a living host. By means of this novel method biological compounds can be generated which have a no or at least a reduced immunogenicity when exposed to the immune system of a given species and compared with the relevant non-modified entity. Thus the invention relates also to novel biological molecules, especially proteins and antibodies, obtained by the method according to the invention.
</p> |
申请公布号 |
EP1998266(A3) |
申请公布日期 |
2009.02.11 |
申请号 |
EP20080011838 |
申请日期 |
2002.02.18 |
申请人 |
MERCK PATENT GMBH |
发明人 |
CARR, FRANCIS, JOSEPH, DR.;CARTER, GRAHAM;JONES, TIM, DR.;HAMILTON, ANITA, A.;WILLIAMS, STEPHEN |
分类号 |
G01N33/50;A61K9/70;A61K38/00;A61K38/11;A61K47/02;A61K47/12;C07K14/00;C07K14/285;C07K14/415;C07K14/47;C07K14/475;C07K14/50;C07K14/505;C07K14/525;C07K14/535;C07K14/54;C07K14/545;C07K14/575;C07K14/59;C07K14/725;C07K16/00;C07K16/18;C07K16/28;C07K16/30;C07K16/46;C07K19/00;C12N9/24;C12N9/54;C12N9/64;C12N9/88;C12N15/09;G01N33/15;G01N33/48;G06F19/16;G06F19/18 |
主分类号 |
G01N33/50 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|