发明名称 |
Janus family kinases and identification of immune modulators |
摘要 |
An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing.
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申请公布号 |
US7488808(B2) |
申请公布日期 |
2009.02.10 |
申请号 |
US20050195197 |
申请日期 |
2005.08.01 |
申请人 |
UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
O'SHEA JOHN J.;LEONARD WARREN J.;JOHNSTON JAMES A.;RUSSELL SARAH M.;MCVICAR DANIEL W.;KAWAMURA MASARU |
分类号 |
C07K16/40;A61K39/395;A61K48/00;C07H21/04;C07K16/18;C12N9/12 |
主分类号 |
C07K16/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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