METHODS AND SYSTEMS FOR ATTENUATING THE TOLERANCE RESPONSE TO A DRUG

摘要

Methods are provided for modulating a drug response comprising determining that a patient has an elevated or reduced susceptibility for a neurological event; outputting a signal that indicates to the patient to administer an acute dosage of a pharmacological agent that is sufficient to modulate the patient's susceptibility for the neurological event, wherein the drug response is modulated. Systems are also provided for treating epilepsy comprising an electrode array configured to receive a signal from a patient; a processing assembly configured to receive and process the signal to determine the patient's susceptibility for a neurological event; an output assembly configured to produce an output that indicates to the patient to administer an acute dosage of a pharmacological agent that is sufficient to reduce the patient's susceptibility for the neurological event, wherein the drug response to the pharmacological agent is attenuated.