发明名称 |
NOVEL CHEMICAL ENTITIES AFFECTING NEUROBLASTOMA TUMOR-INITIATING CELLS |
摘要 |
Disclosed are neuroblastoma tumor-initiating cell inhibiting compositions comprising chemical entities capable of affecting neuroblastoma tumor-initiating cells. Pharmaceutical preparations that include these chemical entities are also provided for the treatment of neuroblastoma. These pharmaceutical preparations are suitable for the treatment of humans, and are particularly suited for the treatment of children of 12 years of age or younger having neuroblastoma. The compositions and pharmaceutical preparations posses reduced normal cell cytotoxicity. The compositions and pharmaceutical preparations may be used alone or together with other conventional neuroblastoma preparations as part of a clinical regimen in the treatment and management of neuroblastoma.
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申请公布号 |
US2009036387(A1) |
申请公布日期 |
2009.02.05 |
申请号 |
US20080206963 |
申请日期 |
2008.09.09 |
申请人 |
THE HOSPITAL FOR SICK CHILDREN |
发明人 |
KAPLAN DAVID R.;SMITH KRISTEN M.;DATTI ALESSANDRO |
分类号 |
A61K31/7048;A61K31/122;A61K31/14;A61K31/34;A61K31/395;A61K31/435;A61K31/44;A61K31/4425;A61K31/4439;A61K31/4709;A61K31/473;A61K31/495;A61K31/498;A61K31/52;A61K31/56;A61K31/58;A61K31/704;A61K31/7068;A61P35/00;C12N5/00;C12N5/095 |
主分类号 |
A61K31/7048 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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