发明名称 |
METHODS AND COMPOSITIONS FOR INCREASING ALPHA-IDURONIDASE ACTIVITY IN THE CNS |
摘要 |
Provided herein are methods and compositions for treating a subject suffering from a deficiency in a-L-Iduronidase in the CNS. The methods include systemic administration of a bifunctional fusion antibody comprising an antibody to a human insulin receptor and an a-L-Iduronidase. A therapeutically effective systemic dose is based on the specific CNS uptake characteristics of human insulin receptor antibody-a-L-Iduronidase fusion antibodies as described herein. |
申请公布号 |
CA2694762(A1) |
申请公布日期 |
2009.02.05 |
申请号 |
CA20082694762 |
申请日期 |
2008.07.25 |
申请人 |
ARMAGEN TECHNOLOGIES, INC. |
发明人 |
PARDRIDGE, WILLIAM M.;BOADO, RUBEN J. |
分类号 |
A61K39/395;A61P25/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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