USE OF A CHROMATOGRAPHY SUBSTRATE FOR REDUCING THE AMOUNT OF ADAMTS13 IN A SOLUTION DERIVED FROM PLASMA

摘要

The invention relates to the use of an ion-exchange chromatography substrate including a resin of the large-pore vinylic polymer type including DEAE groups and a buffer including trisodic citrate, sodium chloride, calcium chloride, glycine and lysine for reducing the amount of ADAMTS13 present in a solution derived from plasma containing a human von Willebrand factor.