摘要 |
Pharmaceutical composition made of microparticles for the slow release of an active substance at least during a period covering the 6th month after injection of said composition, said composition comprising a group of microparticles made of a copolymer of the PLGA type which incorporate an active substance in the form of a water insoluble peptide salt; said copolymer furthermore comprising at least 75 % of lactic acid and an inherent viscosity between 0.1 and 0.9 dl/g, as measured in chloroform at 25 °C and at a polymer concentration of 0.5 g/dL; said microparticles furthermore having a size distribution defined as follows : - D (v,0.1 ) is between 10 and 30 micrometers, - D (v,0.5) is between 30 and 70 micrometers, - D(v,0.9) is between 50 and 1 10 micrometers. |
申请人 |
DEBIO RECHERCHE PHARMACEUTIQUE S.A.;DUCREY, BERTRAND;GARROUSTE, PATRICK;CURDY, CATHERINE;BARDET, MARIE-ANNE;PORCHET, HERVE;LUNDSTROM, EIJA;HEIMGARTNER, FREDERIC |
发明人 |
DUCREY, BERTRAND;GARROUSTE, PATRICK;CURDY, CATHERINE;BARDET, MARIE-ANNE;PORCHET, HERVE;LUNDSTROM, EIJA;HEIMGARTNER, FREDERIC |