DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK

摘要

Compounds fo Formula (I) are effective modulators of INK: wherein X s CR11 or N; X2 s CH or N; R1 and R2 are each independently H, halo, CN, lower alkyl, or -Y1-Y2-Y3-R8, or R1 and R2 together form -O(CH2)nO-, where n is 1 or 2; Y1 is -O- -C(O)- -C(O)O- -C(O)NR9-, -NR9C(O)- -S-, or -SO2-; Y2 is lower alkylene or a bond; Y3 is -O- -C(O)- -C(O)O-, -C(O)NR9-, -NR9C(O)- -SO2-, or a bond; R8 is H, lower alkyl, cycloalkyl, heterocycloalkyl, or -NR9R10, wherein R8 other than H is optionally substituted with lower alkyl, halo or -OH; R9 and R10 are each independently H or lower alkyl; R3 is OH, lower alkyl, lower alkoxy, or -NR9R10; R4 is lower alkyl, phenyl, heterocyclyl, cycloalkyl, heterocycloalkyl, or heteroaryl, and is optionally substituted with lower alkyl, hydroxy, lower alkoxy, halo, nitro, amino, cyano, or halo-lower alkyl; R5 and R6 are each independently H, halo, cyano, lower alkyl, -CF3, lower alkoxy, -OCHF2, -NO2, or -NR9R10; R11 is H, lower alkyl, lower cycloalkyl, or phenyl; or a pharmaceutically acceptable salt thereof.