| 摘要 |
PROBLEM TO BE SOLVED: To provide an apoptosis-inducing method for treating cancer cells with an isolated binding partner of a Cripto-1 protein, Pim-1 protein or an antigen existing in a colon cancer cell lysate. SOLUTION: The binding partner inhibits growth of one or more cancer cell types and is able to be used as an anti-cancer agent for treating cancer in a subject, and also used in a method for inducing apoptosis in a cancer cell and a method for sensitising a cancer cell to a cytotoxic compound. In addition, a cancer vaccine is provided. The vaccine comprises a Cripto-1 protein (or an antigenic fragment thereof), Pim-1 protein (or an antigenic fragment thereof) or an antigen existing in a colon cancer cell lysate, or an expressible DNA molecule encoding the Cripto-1 protein (or an antigenic fragment thereof), Pim-1 protein (or an antigenic fragment thereof) or the antigen existing in a colon cancer cell lysate. COPYRIGHT: (C)2009,JPO&INPIT
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