METHOD FOR PRODUCING PEPTIDE

摘要

It is intended to provide a method for producing a peptide characterized by, in a peptide containing an amino acid residue having an -SH group, converting the -SH group into an -OH group, and including the following steps (a) to (c): (a) a step of converting an -SH group in a peptide into an -SMe group by reacting the -SH group with a methylating agent; (b) a step of forming a reaction intermediate by reacting the -SMe group obtained in the step (a) with a cyanide agent; and (c) a step of converting the reaction intermediate obtained in the step (b) into a peptide containing an amino acid residue having an -OH group under a more basic condition compared with the step (b).