发明名称 |
ACETAMINOPHEN FINE PARTICLE USING SUPERCRITICAL AND SUBCRITICAL FLUID PROCESS AND A MANUFACTURING PROCESS THEREOF |
摘要 |
Acetaminophen fine particles are provided to control the crystal polymorphism of drug by diversifying parameters in manufacturing the particles and to be usable for an immediate release analgesic composition due to improved elution rate. A method for manufacturing acetaminophen fine particles comprises (a) a step for preparing the solution by dissolving acetaminophen in ethylacetate or tetrahydrofurane; (b) a step for preparing the acetaminophen fine particles by mixing carbon dioxide of 0-45 °C and 35-200 pressure(atm) and the solution obtained from the (a) step in a precipitator; (c) a step for removing an organic solvent remaining in particles by using the supercritical carbon dioxide of 0-45 °C and 35-200 pressure(atm); and (d) a step for collecting the fine particles generated through the pressure reduction of the inside of the precipitator.
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申请公布号 |
KR100881407(B1) |
申请公布日期 |
2009.02.05 |
申请号 |
KR20070091886 |
申请日期 |
2007.09.11 |
申请人 |
SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION |
发明人 |
LEE, YOUN WOO;CHU, JUN HO;LI GUANGHUA;ROW, KYUNG HO |
分类号 |
C07C233/07;C07C233/01 |
主分类号 |
C07C233/07 |
代理机构 |
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代理人 |
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地址 |
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