发明名称 |
Truncated Fragments of Alpha-Synuclein in Lewy Body Disease |
摘要 |
The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in tricine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue 117 and before residue 126 of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.
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申请公布号 |
US2009035217(A1) |
申请公布日期 |
2009.02.05 |
申请号 |
US20080040739 |
申请日期 |
2008.02.29 |
申请人 |
ELAN PHARMACEUTICALS, INC. |
发明人 |
CHILCOTE TAMIE J.;GOLDSTEIN JASON;ANDERSON JOHN P.;WALKER DONALD |
分类号 |
A61K49/00;A01K67/027;A61K38/00;A61K39/395;A61P25/00;C07K16/18;C12N9/50;C12Q1/02;G01N33/00 |
主分类号 |
A61K49/00 |
代理机构 |
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