发明名称 |
ACYLATED BETULIN AND DIHYDROBETULIN DERIVATIVES, PREPARATIONTHEREOF AND USE THEREOF |
摘要 |
Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have formulae (I) or pharmaceutically acceptable salts thereof; wherein R1 is a C2-C20 substituted or unsubstituted carboxyacyl, R2 is a C2-C20 substituted or unsubstituted carboxyacyl; and R3 is hydrogen, halogen, amino, optionally substituted mono-- or di-alkylamino, or -OR4, where R4 is hydrogen, C1-4 alkanoyl, benzoyl, or C2-C20 substituted or unsubstituted carboxyacyl; wherein the dashed line represents an optional double bond between C20 and C29.
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申请公布号 |
CA2322868(C) |
申请公布日期 |
2009.02.03 |
申请号 |
CA19992322868 |
申请日期 |
1999.03.02 |
申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;BBI BIOTECH RESEARCH LABORATORIES, INC. |
发明人 |
WANG, HUI-KANG;COSENTINO, LOUIS MARK;SUN, I-CHEN;LEE, KUO-HSIUNG |
分类号 |
A61K31/53;C07J63/00;A61K31/225;A61K31/56;A61K31/575;A61P31/12;A61P31/14;A61P31/18;C07C69/013;C07J53/00 |
主分类号 |
A61K31/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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