Chimeric vectors

摘要

Disclosed are AAV capsids that can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. A single amino acid insertion or substitution from AAV into the capsid structure of another AAV to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent. Particularly an insertion into the capsid protein at position 264.