摘要 |
<p>The invention relates to novel 18-methyl-19-nor-androst-4-en-17,17- spiroether of general formula (I), where Z = O, two H, =NOR or =NNHSO<sub>2</sub>R, R = H, or straight or branched chain C<sub>1-4</sub> or C<sub>3-4</sub>alkyl, R4 = H, halogen, or CF<sub>3</sub> and R6 and/or R7 are alpha- or ÿ-positioned and R6 and R7 independently = H or straight or branched chain C<sub>1-4</sub> or C<sub>3-4</sub>alkyl or a straight or branched chain C<sub>2-4</sub> or C<sub>3-4</sub>alkylene or a saturated C<sub>3-5</sub> cycloalkyl, or together form a methylene group or a double bond. The novel compounds have gestagenic and antimineralcorticoid action.</p> |