| 发明名称 |
Anti-AlphaVBeta3 Recombinant Human Antibodies, Nucleic Acids Encoding Same |
| 摘要 |
The invention provides enhanced LM609 grafted antibodies exhibiting selective binding affinity to alphavbeta3, or a functional fragment thereof. The invention also provides nucleic acid molecules encoding the enhanced LM609 grafted antibodies. Additionally provided are methods of inhibiting a function of alphavbeta3 by contacting alphavbeta3 with an enhanced LM609 grafted antibody.
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| 申请公布号 |
US2009023900(A1) |
申请公布日期 |
2009.01.22 |
| 申请号 |
US20080102818 |
申请日期 |
2008.04.14 |
| 申请人 |
APPLIED MOLECULAR EVOLUTION, INC. |
发明人 |
HUSE WILLIAM D.;WU HERREN |
| 分类号 |
C07K16/18;C12N15/09;A61K39/395;A61P9/10;A61P17/02;A61P17/06;A61P19/02;A61P19/10;A61P21/00;A61P27/02;A61P29/00;A61P35/00;A61P35/04;A61P43/00;C07K16/28;C12N15/12;C12N15/13 |
主分类号 |
C07K16/18 |
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