发明名称 |
COMPOSITIONS AND METHODS FOR ALZHEIMER'S DISEASE |
摘要 |
The present invention concerns methods and compositions of use for treatment of Alzheimer's Disease (AD). In certain embodiments, the methods concern preparation of phage-display single chain antibody libraries and screening against amyloid-beta (Abeta) protein or peptide. Anti-Abeta antibodies are selected and sequenced. In certain embodiments, synthetic Abeta binding peptides are designed and prepared, using portions of the anti-Abeta antibody sequences. The antibodies and peptides are of use for treatment of AF or for treatment of individuals at risk of developing AD. Compositions comprising anti-Abeta antibodies or Abeta binding peptides are also disclosed.
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申请公布号 |
US2009023627(A1) |
申请公布日期 |
2009.01.22 |
申请号 |
US20070773349 |
申请日期 |
2007.07.03 |
申请人 |
REGENTS OF THE UNIVERSITY OF COLORADO |
发明人 |
MANUCHARYAN KAREN;GEVORGYAN GOHAR |
分类号 |
A61K38/02;A61P25/28;C07K2/00;C07K7/08;C07K14/00 |
主分类号 |
A61K38/02 |
代理机构 |
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地址 |
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