发明名称 |
PROCESS AND INTERMEDIATE FOR THE PRODUCTION OF A TERTIARY ALCOHOL AS AN INTERMEDIATE IN THE SYNTHESIS OF MONTELUKAST |
摘要 |
The tertiary alcohol a-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy- 1-methylethyl)benzenepropanol, the (aS)-enantioner of which is an intermediate in the production of montelukast, is produced by reacting the novel lactone of formula (II) with a methylmagnesium halide in an ethereal solvent in the presence of lanthanum trichloride and lithium chloride. The lactone II can be prepared by reacting a corresponding hydroxyester with a Grignard reagent in the absence of a lanthanoid compound or with a strong base. |
申请公布号 |
WO2009010230(A2) |
申请公布日期 |
2009.01.22 |
申请号 |
WO2008EP05637 |
申请日期 |
2008.07.10 |
申请人 |
LONZA LTD;MCGARRITY, JOHN;DJOJO, FRANCIS |
发明人 |
MCGARRITY, JOHN;DJOJO, FRANCIS |
分类号 |
C07D215/18;C07D405/10 |
主分类号 |
C07D215/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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