<p>This invention relates to a mutant E. coli heat-labile enterotoxin (LT) subunit A that can be used as an adjuvant. This subunit A mutant contains an amino acid substitution at a position corresponding to position 61 of a wild-type LT. An LT containing this mutated subunit A exhibits reduced toxicity compared to its wild type counterpart.</p>
申请公布号
WO2009011707(A1)
申请公布日期
2009.01.22
申请号
WO2007US75801
申请日期
2007.08.13
申请人
DEVELOPMENT CENTER FOR BIOTECHNOLOGY;HSU, YU-SHEN;LIN, YOUNG-SUN;YUAN, TA-TUNG