摘要 |
<p>The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed.</p> |
申请人 |
MEDAREX, INC.;TERRETT, JONATHAN, ALEXANDER;LU, LI-SHENG;HUANG, HAICHUN;YAO, DAPENG;PAN, CHIN;LEBLANC, HEIDI;SPROUL, TIMOTHY;YAMANAKA, MARK |
发明人 |
TERRETT, JONATHAN, ALEXANDER;LU, LI-SHENG;HUANG, HAICHUN;YAO, DAPENG;PAN, CHIN;LEBLANC, HEIDI;SPROUL, TIMOTHY;YAMANAKA, MARK |